Description

(S)-(+)-Ibuprofen-D3 is a stable isotopically labeled analog of the non-steroidal anti-inflammatory drug (NSAID) (S)-ibuprofen, where three hydrogen atoms are replaced by deuterium. This compound is an essential internal standard and reference material for the accurate quantification and pharmacokinetic profiling of ibuprofen in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and bioanalytical studies to ensure data integrity and regulatory compliance.

Application

• Bioanalytical Internal Standard: Serves as a critical internal standard for the precise quantification of (S)-ibuprofen in plasma, serum, and other biological fluids via mass spectrometry.
• Pharmacokinetic & Metabolism Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) research to track the fate of the active enantiomer of ibuprofen in vivo.
• Method Development & Validation: Essential for developing and validating robust, sensitive, and specific LC-MS/MS methods in compliance with FDA and ICH guidelines.
• Doping Control & Forensic Analysis: Employed as a reference material in sports anti-doping and forensic toxicology laboratories for the confirmation of ibuprofen.
• Stable Isotope Tracer Studies: Utilized in clinical research to investigate metabolic pathways and enantiomer-specific disposition of ibuprofen.
• Pharmaceutical Quality Control: Acts as a reference standard for the assay and impurity profiling of enantiomerically pure (S)-ibuprofen in active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	(S)-(+)-Ibuprofen-D3
CAS No.	1329643-44-8
Molecular Formula	C13H15D3O2
Molecular Weight	209.30 g/mol
Synonyms	(S)-(+)-2-(4-Isobutylphenyl)propionic-3,3,3-d3 Acid; (S)-Ibuprofen-d3; Dexibuprofen-d3; (2S)-2-[4-(2-Methylpropyl)phenyl]propionic-3,3,3-d3 Acid; (+)-(S)-Ibuprofen-D3; [2-(4-Isobutylphenyl)propionyl-3,3,3-d3]-(S)-acid; (S)-α-Methyl-4-(2-methylpropyl)benzeneacetic-3,3,3-d3 Acid
EINECS	Contact for details

Quality Control

Our (S)-(+)-Ibuprofen-D3 is manufactured under strict quality control protocols to ensure high chemical and isotopic purity, essential for reliable analytical results. Each batch is characterized by NMR, HPLC, and mass spectrometry to confirm identity, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications for assay, enantiomeric excess, isotopic enrichment, and related substances. Our quality system supports compliance with cGMP standards for reference materials used in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.