Description

Apovincaminic Acid-D4 is a deuterated analog of apovincaminic acid, a key intermediate in the synthesis of vincamine alkaloids. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical workflows. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in pharmacokinetic studies, metabolic profiling, and quality control of vinca alkaloid-based drugs.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of vincamine and related alkaloids in biological matrices (plasma, serum, tissue) during bioanalytical method development and validation.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track and quantify the parent drug and its metabolites.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants in active pharmaceutical ingredient (API) batches.
• Stable Isotope Dilution Analysis: Enables highly accurate concentration measurements in complex samples, minimizing matrix effects and improving data reproducibility.
• Clinical Research: Supports clinical trial studies requiring high-precision monitoring of drug concentration levels in patients.
• Reference Material: Serves as a certified reference material (CRM) for calibrating analytical instruments and validating testing methods in GMP/GLP environments.

Basic Information

Product Name	Apovincaminic Acid-D4
CAS No.	1329624-60-3
Molecular Formula	C21H22D4N2O3
Molecular Weight	354.47 g/mol
Synonyms	Apovincaminic Acid-d4; (15S,17S)-Eburnamenine-14-carboxylic Acid-d4; 14-Carboxyeburnamenine-d4; Vincaminic Acid-d4 (impurity); Deuterated Apovincaminic Acid; 2,3,4,4a-Tetradeutero-apovincaminic Acid; Apovincaminic Acid (D4); EINECS Contact for details

Quality Control

Every batch of Apovincaminic Acid-D4 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, verified by advanced techniques including NMR (1H, 13C) and high-resolution mass spectrometry (HRMS). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data for identity, purity (HPLC), isotopic enrichment, and residual solvents. Our quality commitment ensures the material is suitable for the most demanding GLP and GMP regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.