Description

5-Chloro-2-Methyl-3-Isothiazolone-D3 is a deuterated isotopologue of the widely used industrial biocide 5-Chloro-2-Methyl-3-Isothiazolone (CMIT). This compound is specifically designed for use as an internal standard in analytical chemistry, enabling precise quantification and method validation in complex matrices. It is an essential tool for researchers and quality control laboratories in the chemical, pharmaceutical, and water treatment industries who require high-fidelity analytical results. The deuterium labeling provides a distinct mass signature for accurate detection via mass spectrometry.

Application

• Analytical Reference Standard: Primary use as an internal standard for the accurate quantification of CMIT in various samples via LC-MS or GC-MS.
• Pharmaceutical Research: Used in metabolism studies, pharmacokinetic analysis, and stability testing of related bioactive compounds.
• Environmental Monitoring: Critical for tracing and quantifying biocide residues in industrial wastewater, cooling systems, and environmental samples.
• Product Development & Quality Assurance: Supports method development and validation for manufacturers of paints, coatings, adhesives, and personal care products containing isothiazolinone preservatives.
• Regulatory Compliance Testing: Facilitates testing to ensure compliance with global regulations (e.g., EPA, REACH) regarding biocide levels in consumer and industrial products.

Basic Information

Product Name	5-Chloro-2-Methyl-3-Isothiazolone-D3
CAS No.	1329611-34-8
Molecular Formula	C4H2D3ClNOS
Molecular Weight	151.62 g/mol (deuterated form)
Synonyms	CMIT-D3; 5-Chloro-2-methyl-4-isothiazolin-3-one-d3; 2-Methyl-5-chloro-3-isothiazolone-d3; 3(2H)-Isothiazolone, 5-chloro-2-methyl-, D3-labeled; Methylchloroisothiazolinone-D3; MCI-D3; Deuterated 5-Chloro-2-methyl-3(2H)-isothiazolone; Kathon CG-D3 (related to trade name)
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-2-Methyl-3-Isothiazolone-D3 is produced and analyzed under strict quality protocols to ensure the highest isotopic purity and chemical integrity required for analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing parameters such as isotopic purity, chemical purity, and solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. For long-term storage, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Purity (D3)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.