Description

Eniluracil-13C,15N2 is a stable isotope-labeled analog of the chemotherapeutic agent Eniluracil, specifically enriched with carbon-13 and nitrogen-15 at designated positions. This compound is essential for advanced pharmacokinetic and metabolic studies, providing an internal standard for precise quantification via mass spectrometry. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug development and bioanalytical method validation for oncology research.

Application

• Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of Eniluracil in biological matrices.
• Critical for conducting drug metabolism and pharmacokinetics (DMPK) studies to understand absorption, distribution, metabolism, and excretion (ADME) profiles.
• Facilitates bioanalytical method development and validation in compliance with FDA and ICH guidelines.
• Enables metabolic pathway elucidation and stable isotope tracer studies in preclinical and clinical research.
• Supports quality control and assurance in the manufacturing of pharmaceutical reference standards.
• Applied in academic research focusing on the mechanism of action of dihydropyrimidine dehydrogenase (DPD) inhibitors.

Basic Information

Product Name	Eniluracil-13C,15N2
CAS No.	1329556-69-5
Molecular Formula	C613CH615N2O2
Molecular Weight	~130.09 g/mol (labeled)
Synonyms	5-Ethynyluracil-13C,15N2; 5-Ethynyl-2,4(1H,3H)-pyrimidinedione-13C,15N2; GW 776C85-13C,15N2; 776C85-13C,15N2; 5-Ethynyl-1H-pyrimidine-2,4-dione-13C,15N2; Stable Isotope Labeled Eniluracil; [13C,15N2]-Eniluracil
EINECS	Contact for details

Quality Control

Our Eniluracil-13C,15N2 is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic enrichment and chemical purity. Certificates of Analysis (COA) are provided, detailing specifications for isotopic purity, chemical purity, and residual solvents. Production is aligned with cGMP principles for research materials, ensuring traceability and consistency for critical bioanalytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product at 2-8°C under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity	≥ 99 atom % 13C; ≥ 99 atom % 15N
Chemical Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.