Description

Modafinil-D5 Sulfone is a deuterated internal standard of the primary metabolite of the wakefulness-promoting agent Modafinil. This high-purity reference material is essential for ensuring the accuracy and reliability of quantitative analytical methods, particularly in pharmacokinetic and bioequivalence studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities specializing in neuroscience and analytical chemistry.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the precise measurement of Modafinil and its metabolites in biological matrices.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of Modafinil.
• Bioanalytical Method Development & Validation: Critical for developing and validating robust, GLP-compliant analytical methods for clinical and preclinical trials.
• Forensic and Anti-Doping Analysis: Employed in confirmatory testing for the presence of Modafinil and its sulfone metabolite in forensic toxicology and sports anti-doping laboratories.
• Metabolite Identification and Quantification: Aids in the specific identification and accurate quantification of Modafinil sulfone, the major circulating metabolite, in complex samples.
• Quality Control in Reference Material Production: Serves as a certified reference material for calibrating instruments and verifying the purity of in-house standards.

Basic Information

Item	Detail
Product Name	Modafinil-D5 Sulfone
CAS No.	1329496-95-8
Molecular Formula	C15H10D5NO3S
Molecular Weight	292.38 g/mol
Synonyms	2-[(Diphenylmethyl)sulfinyl]-N-(1,1,2,2,2-pentadeuterioethyl)acetamide; Modafinil Sulfone-d5; Modafinil Acid Sulfone-d5; Modafinil Metabolite Sulfone-d5; (±)-Modafinil Sulfone-d5; 2-[(Diphenylmethyl)sulfonyl]acetamide-d5; (RS)-Modafinil Sulfone-d5; Deuterated Modafinil Sulfone
EINECS	Contact for details

Quality Control

Every batch of Modafinil-D5 Sulfone is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, confirmed by advanced techniques including NMR (1H, 13C), HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing batch-specific results for identity, purity (HPLC assay), isotopic enrichment, and residual solvents are provided and traceable to internally certified reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.