Description

3,4-Di-o-Benzyl Dl-Threo-Droxidopa-13C2,15N Hydrochloride is a stable, isotopically labeled derivative of the amino acid precursor Droxidopa, specifically designed for advanced research and analytical applications. This compound is of critical importance as a high-purity internal standard and reference material for quantitative mass spectrometry, ensuring accurate and reliable data in pharmacokinetic and metabolic studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical chemists working on the development and validation of bioanalytical methods for neuropharmacology and related fields.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the precise quantification of Droxidopa and its metabolites in complex biological matrices like plasma, serum, and urine.
• Metabolic Pathway Tracing: Utilized in stable isotope labeling studies to elucidate the absorption, distribution, metabolism, and excretion (ADME) profiles of therapeutic agents.
• Pharmaceutical R&D: Supports method development and validation in the research of treatments for neurogenic orthostatic hypotension (nOH), Parkinson's disease, and other neurological conditions.
• Quality Control & Assurance: Acts as a certified reference material (CRM) to calibrate equipment and verify the accuracy of analytical results in GLP/GMP-compliant environments.
• Isotope Dilution Mass Spectrometry (IDMS): Enables highly accurate and precise measurements, essential for clinical research and regulatory submissions to agencies like the FDA and EMA.

Basic Information

Product Name	3,4-Di-o-Benzyl Dl-Threo-Droxidopa-13C2,15N Hydrochloride
CAS No.	1329488-61-0
Molecular Formula	C19H22ClNO4 (with 13C2, 15N labeling)
Molecular Weight	Contact for details
Synonyms	DL-threo-3,4-Di-O-benzyl-Droxidopa-13C2,15N hydrochloride; (2RS,3SR)-2-Amino-3-(3,4-bis(benzyloxy)phenyl)-3-hydroxypropanoic-13C2,15N acid hydrochloride; 13C2,15N-Labeled L-DOPS benzyl ester hydrochloride; Isotopically labeled Nordihydroxyphenylserine derivative; Droxidopa-13C2,15N internal standard; 3,4-Di-O-benzyl-DL-threo-DOPS-13C2,15N HCl
EINECS	Contact for details

Quality Control

Our 3,4-Di-o-Benzyl Dl-Threo-Droxidopa-13C2,15N Hydrochloride is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing chemical purity, isotopic purity (enrichment), and chromatographic profile. We adhere to industry best practices, and specifications can be tailored to meet specific research or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 99 atom % 15N
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.