Description

Des[4-(2-Cyclopropylmethoxy)] Betaxolol-D5 Hydrochloride is a deuterated analog of the β-adrenergic receptor antagonist betaxolol, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control units requiring precise measurement of betaxolol and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the quantitative bioanalysis of betaxolol in biological matrices (plasma, serum, urine).
• Pharmaceutical R&D: Used in method development and validation for pharmacokinetic (PK) and pharmacodynamic (PD) studies during drug development.
• Metabolite Profiling: Aids in the identification and quantification of betaxolol metabolites in metabolism and excretion studies.
• Quality Control & Assurance: Ensures assay precision and accuracy in the quality control testing of betaxolol active pharmaceutical ingredients (APIs) and finished dosage forms.
• Forensic & Clinical Toxicology: Supports accurate quantification in forensic analysis and therapeutic drug monitoring (TDM) programs.
• Regulatory Submissions: Provides the data integrity required for compliant submissions to regulatory bodies like the FDA and EMA.

Basic Information

Product Name	Des[4-(2-Cyclopropylmethoxy)] Betaxolol-D5 Hydrochloride
CAS No.	1329488-43-8
Molecular Formula	C18H24D5NO3·HCl
Molecular Weight	~348.95 g/mol (for D5 isotopologue)
Synonyms	Betaxolol-d5 Hydrochloride; 1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol-d5 Hydrochloride; Des(4-(2-Cyclopropylmethoxy)ethyl) Betaxolol-d5 HCl; Deuterated Betaxolol Internal Standard; Betaxolol (D5) Hydrochloride; Betaxolol-d5 HCl; (RS)-1-(4-[2-(Cyclopropylmethoxy)ethyl]phenoxy)-3-(isopropylamino)propan-2-ol-d5 hydrochloride
EINECS	Contact for details

Quality Control

Our deuterated internal standards are produced under strict quality-controlled conditions to ensure the highest isotopic purity and chemical stability. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, LC-MS, and HPLC. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (≥95% by HPLC), and confirming structural identity. Our quality system supports compliance with GMP/GLP principles for use in regulated studies.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.