Description

O6-(2-Hydroxy-1-Methylethyl)-2'-Deoxyguanosine is a chemically modified nucleoside derivative, specifically an O6-alkylated analog of 2'-deoxyguanosine. This compound is of significant value in biochemical and pharmacological research, serving as a critical tool for studying DNA alkylation damage, repair mechanisms, and the development of novel therapeutic agents. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in oncology research, DNA repair studies, and the synthesis of nucleotide-based probes.

Application

• Biochemical Research: Used as a standard or substrate in enzymatic assays to study the activity of DNA repair enzymes like O6-alkylguanine-DNA alkyltransferase (AGT).
• Oncology & Pharmacology: Serves as a key intermediate in the research and development of chemotherapeutic agents that target DNA alkylation pathways.
• DNA Damage & Repair Studies: Essential for in vitro and in vivo models investigating the mechanisms and consequences of specific O6-alkylguanine lesions in DNA.
• Nucleotide Chemistry: Acts as a building block for the synthesis of modified oligonucleotides used as probes or tools in molecular biology.
• Toxicology Research: Employed to understand the genotoxic effects of alkylating agents and to evaluate potential protective compounds.
• Academic Research: Utilized in university laboratories for fundamental studies in chemical biology, genetics, and carcinogenesis.

Basic Information

Product Name	O6-(2-Hydroxy-1-Methylethyl)-2'-Deoxyguanosine
CAS No.	1327339-21-8
Molecular Formula	C13H19N5O5
Molecular Weight	325.32 g/mol
Synonyms	O6-(2-Hydroxypropyl)-2'-deoxyguanosine; O6-HP-dG; 2'-Deoxy-O6-(2-hydroxypropyl)guanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-[(2-hydroxypropyl)amino]-1H-purin-2-one; O6-(1-Hydroxypropan-2-yl)-2'-deoxyguanosine; dG-O6-HP; Modified Deoxyguanosine Nucleoside
EINECS	Contact for details

Quality Control

Our O6-(2-Hydroxy-1-Methylethyl)-2'-Deoxyguanosine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.