Description

6-(Difluoromethyl)Pyridin-2-Amine is a high-purity, advanced pharmaceutical intermediate featuring a difluoromethylated pyridine scaffold. This compound matters for its critical role in modern medicinal chemistry, where the difluoromethyl group is a key bioisostere used to modulate the pharmacokinetic and metabolic properties of drug candidates. It is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, where the pyridine core provides essential biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in organometallic chemistry and catalysis.
• Material Science Research: Employed in the development of novel organic electronic materials and functional polymers.
• Chemical Biology Probes: Utilized as a scaffold for designing molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis services catering to pharmaceutical and biotechnology clients.

Basic Information

Product Name	6-(Difluoromethyl)Pyridin-2-Amine
CAS No.	1315611-68-7
Molecular Formula	C6H6F2N2
Molecular Weight	144.12 g/mol
Synonyms	2-Amino-6-(difluoromethyl)pyridine; 6-(Difluoromethyl)-2-pyridinamine; 2-Pyridinamine, 6-(difluoromethyl)-; 6-Difluoromethyl-pyridin-2-ylamine; 2-Amino-6-difluoromethylpyridine; 6-Difluoromethyl-2-aminopyridine; 1315611-68-7
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethyl)Pyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.