Description

Osilodrostat (Lci699) Phosphate is a potent and selective inhibitor of aldosterone synthase (CYP11B2), a key enzyme in the biosynthesis of aldosterone. This compound is of significant interest for the research and development of novel therapeutics targeting conditions of aldosterone excess, such as primary aldosteronism and certain forms of hypertension. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and CROs engaged in endocrinology, cardiovascular disease research, and preclinical drug development.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of treatments for hyperaldosteronism.
• Biochemical Assays: Used as a selective tool compound in in vitro enzymatic assays to study CYP11B2 inhibition kinetics and mechanism of action.
• Preclinical Studies: Employed in animal models to investigate the pharmacokinetics, pharmacodynamics, and efficacy of aldosterone synthase inhibition.
• Metabolic Pathway Analysis: Aids in the study of the steroidogenesis pathway and the role of aldosterone in cardiovascular and renal physiology.
• Quality Control & Analytical Testing: Functions as a high-purity analytical standard for HPLC, LC-MS, or NMR methods in pharmaceutical quality control laboratories.

Basic Information

Product Name	Osilodrostat (Lci699) Phosphate
CAS No.	1315449-72-9
Molecular Formula	C13H10FN3O • H3PO4
Molecular Weight	369.23 g/mol (free base: 267.24 g/mol)
Synonyms	LCI699 phosphate; 4-(5,6-Dihydro-2-benzothiophen-7-yl)-1H-imidazole phosphate; Osilodrostat phosphate; Isturisa (trade name, phosphate salt); Aldosterone synthase inhibitor LCI699 phosphate; (R)-4-(5,6-Dihydro-2-benzothiophen-7-yl)-1H-imidazole phosphate
EINECS	Contact for details

Quality Control

Our Osilodrostat Phosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, residual solvent analysis, and identity confirmation (IR, NMR, MS). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research-grade and cGMP standards for API intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.