Description

3-Fluoro-Cyclobutanesulfonyl Chloride is a high-purity, versatile sulfonyl chloride derivative featuring a fluorinated cyclobutane ring. This compound serves as a critical building block in advanced organic synthesis, enabling the introduction of the sulfonamide functional group with enhanced metabolic stability and lipophilicity. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including kinase inhibitors and protease inhibitors.
• Agrochemical Synthesis: Used to create novel sulfonamide herbicides and fungicides with improved efficacy and environmental profiles.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Chemical Biology Probes: Employed in the design of activity-based probes (ABPs) and covalent inhibitors for target identification and validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API (Active Pharmaceutical Ingredient) development projects.

Basic Information

Product Name	3-Fluoro-Cyclobutanesulfonyl Chloride
CAS No.	1314964-82-3
Molecular Formula	C4H6ClFO2S
Molecular Weight	172.60 g/mol
Synonyms	3-Fluorocyclobutane-1-sulfonyl chloride; 3-Fluorocyclobutanesulfonyl chloride; Cyclobutanesulfonyl chloride, 3-fluoro-; 1-Sulfonylchloride-3-fluorocyclobutane
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-Cyclobutanesulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality protocols are designed to support regulatory filings in target industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and purity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.