Description

(5-Chloro-2-Fluorophenyl)Methanesulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative serving as a critical building block in advanced organic synthesis. Its value lies in enabling the precise introduction of the (5-chloro-2-fluorophenyl)methanesulfonyl moiety, a key functional group for modulating the biological activity and physicochemical properties of target molecules. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine-tuning compound libraries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the chloro-fluoro-phenyl group contributes to enhanced efficacy and environmental profile.
• Chemical Biology & Proteomics: Acts as a reactive handle for activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors, leveraging its sulfonyl chloride reactivity.
• Material Science Research: Employed in the synthesis of specialized monomers and polymers, such as sulfonated materials for ion-exchange membranes or advanced coatings.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects, supporting R&D efforts in fine chemical and contract manufacturing organizations (CMOs).

Basic Information

Product Name	(5-Chloro-2-Fluorophenyl)Methanesulfonyl Chloride
CAS No.	1314961-07-3
Molecular Formula	C7H5Cl2FO2S
Molecular Weight	243.08 g/mol
Synonyms	1-(Chlorosulfonylmethyl)-5-chloro-2-fluorobenzene; 2-Fluoro-5-chlorobenzylsulfonyl chloride; (5-Chloro-2-fluorobenzyl)sulfonyl chloride; α-Chlorosulfonyl-5-chloro-2-fluorotoluene; 5-Chloro-2-fluoro-α-(chlorosulfonyl)toluene; 2-Fluoro-5-chloro-α-chlorosulfonyltoluene; 1-Chloro-4-(chlorosulfonylmethyl)-2-fluorobenzene
EINECS	Contact for details

Quality Control

Our (5-Chloro-2-Fluorophenyl)Methanesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.