Description

(4-(Chloromethyl)Phenyl)Methanesulfonyl Chloride is a versatile and highly reactive bifunctional organic intermediate, crucial for constructing complex molecular architectures. Its dual functionality, featuring both a chloromethyl and a methanesulfonyl chloride group, makes it an invaluable building block for medicinal chemistry and advanced material synthesis. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including kinase inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides with sulfonyl-containing bioactive moieties.
• Polymer Chemistry: Serves as a cross-linking agent or monomer for producing specialty polymers and resins with tailored properties.
• Chemical Biology: Employed in the design and synthesis of activity-based probes (ABPs) and PROTACs (Proteolysis Targeting Chimeras) for target identification and validation.
• Material Science: Building block for creating advanced materials such as liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs).
• Custom Synthesis: Essential reagent for contract research organizations (CROs) and CDMOs (Contract Development and Manufacturing Organizations) performing bespoke organic synthesis.

Basic Information

Product Name	(4-(Chloromethyl)Phenyl)Methanesulfonyl Chloride
CAS No.	1314928-78-3
Molecular Formula	C8H8Cl2O2S
Molecular Weight	239.12 g/mol
Synonyms	4-(Chloromethyl)benzenesulfonyl chloride; 1-(Chloromethyl)-4-(chlorosulfonyl)benzene; p-(Chloromethyl)benzenesulfonyl chloride; 4-(Chloromethyl)phenylmethanesulfonyl chloride; α-Chloro-p-toluenesulfonyl chloride; (4-Chloromethylphenyl)sulfonyl chloride; Benzenesulfonyl chloride, 4-(chloromethyl)-
EINECS	Contact for details

Quality Control

Our (4-(Chloromethyl)Phenyl)Methanesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP standards where applicable, ensuring reliability for your critical research and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.