Description

3,3-Difluoro-Propane-1-Sulfonyl Chloride is a versatile and highly reactive organofluorine building block, primarily used as a key sulfonylating agent in advanced organic synthesis. Its value lies in introducing the difluoroalkyl sulfonyl moiety, a crucial functional group for modulating the physicochemical and biological properties of target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, particularly for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical reagent for synthesizing sulfonamide-based drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the creation of novel herbicides and fungicides with enhanced activity and environmental profiles.
• Functional Material Precursor: Serves as a building block for sulfonyl-containing polymers, liquid crystals, and electronic materials.
• Chemical Biology Probes: Employed in the design of activity-based probes and covalent inhibitors for target identification and validation.
• Peptide Modification: Facilitates the site-specific introduction of sulfonyl groups into peptides and proteins.
• Cross-Coupling Reactions: Acts as an electrophile in metal-catalyzed cross-coupling reactions to construct complex molecular architectures.

Basic Information

Item	Detail
Product Name	3,3-Difluoro-Propane-1-Sulfonyl Chloride
CAS No.	1314907-49-7
Molecular Formula	C3H5ClF2O2S
Molecular Weight	178.58 g/mol
Synonyms	3,3-Difluoropropane-1-sulfonyl chloride; 3,3-Difluoropropylsulfonyl chloride; 1-Chlorosulfonyl-3,3-difluoropropane; 3,3-Difluoro-1-propanesulfonyl chloride; 1314907-49-7; DFPS-Cl; 3,3-Difluoropropanesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-Propane-1-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP standards where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.