Description

Tmp269 CAS NO 1314890-29-3 is a potent and selective small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of proteins, specifically targeting the second bromodomain (BD2). This compound is a critical research tool for investigating epigenetic regulation and its role in various disease pathways. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of oncology, immunology, and inflammatory disease studies.

Application

• Biomedical Research: A key reagent for studying the biological functions and therapeutic potential of BET bromodomain proteins, particularly BRD2, BRD3, BRD4, and BRDT.
• Oncology Research: Used in in vitro and in vivo studies to explore the role of epigenetic dysregulation in cancer cell proliferation, survival, and tumor progression.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the design and screening of novel BD2-selective BET inhibitors.
• Immunology & Inflammation Studies: Employed to investigate the modulation of gene expression in immune cells and its impact on inflammatory responses and autoimmune conditions.
• Chemical Biology: Used as a probe to understand chromatin remodeling, transcriptional regulation, and other epigenetic mechanisms.
• Academic & Institutional Research: Essential for foundational studies in molecular biology, genetics, and pharmacology within university and government laboratories.

Basic Information

Product Name	Tmp269
CAS No.	1314890-29-3
Molecular Formula	C₂₃H₂₀N₄O₂
Molecular Weight	384.43 g/mol
Synonyms	TMP 269; TMP-269; (R)-N-(4-(2-Hydroxypropan-2-yl)phenyl)-2-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)benzamide; (R)-N-(4-(2-Hydroxypropan-2-yl)phenyl)-2-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)benzenecarboxamide; BET Bromodomain Inhibitor TMP269; BD2-Selective BET Inhibitor; BRD4 BD2 Inhibitor TMP269
EINECS	Contact for details

Quality Control

Our Tmp269 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.