Description

(S)-2-(4-(1,8-Naphthyridin-2-Yl)Phenyl)-n-(1-(4’-Fluoro-3’-(Trifluoromethyl)-[1,1’-Biphenyl]-4-Yl)Ethyl)Acetamide is a high-purity, non-racemic chiral compound designed for advanced pharmaceutical research and development. This molecule serves as a critical pharmacological intermediate or reference standard in the discovery of novel therapeutic agents. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in medicinal chemistry and preclinical studies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Reference Standard: Serves as an analytical standard for method development, quality control, and regulatory submissions in API manufacturing.
• Preclinical Development: Employed in in-vitro and in-vivo studies to assess pharmacokinetics, metabolism, and efficacy.
• Chemical Biology Probe: Used to investigate enzyme function or protein-ligand interactions in biochemical assays.
• Custom Synthesis: A starting material for the custom synthesis of more complex, target-specific molecules for client projects.

Basic Information

Product Name	(S)-2-(4-(1,8-Naphthyridin-2-Yl)Phenyl)-n-(1-(4’-Fluoro-3’-(Trifluoromethyl)-[1,1’-Biphenyl]-4-Yl)Ethyl)Acetamide
CAS No.	1314796-00-3
Molecular Formula	C35H25F4N3O
Molecular Weight	579.59 g/mol
Synonyms	(S)-N-(1-(4'-Fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)ethyl)-2-(4-(1,8-naphthyridin-2-yl)phenyl)acetamide; (S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4'-fluoro-3'-(trifluoromethyl)biphenyl-4-yl)ethyl)acetamide; BMS-986142 (Intermediate); BMS986142 Intermediate; Tyk2 Inhibitor Intermediate; JAK Inhibitor Intermediate; (S)-Enantiomer of a Biphenyl-Naphthyridine Acetamide.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), chiral purity (typically ≥99% ee), and impurity profiles. Our quality protocols are designed to support cGMP and ICH guidelines for pharmaceutical development, ensuring data integrity and traceability for regulatory readiness.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.