Description

3-Hydroxy-Dl-Kynurenine-(Butyric-1,2-13C2) Dihydrobromide is a stable, isotopically labeled salt form of a key tryptophan metabolite, specifically enriched with carbon-13 at the 1 and 2 positions of the butyric acid side chain. This compound is essential for researchers requiring high-purity, chemically defined internal standards for precise quantitative analysis in mass spectrometry-based metabolomic and pharmacokinetic studies. It is primarily used by analytical chemists, pharmaceutical scientists, and research institutions focused on the kynurenine pathway, neurochemistry, and biomarker discovery.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for the accurate measurement of endogenous 3-hydroxykynurenine levels in biological matrices like plasma, serum, and cerebrospinal fluid.
• Metabolomics Research: Enables precise tracking and quantification of tryptophan metabolism through the kynurenine pathway in studies related to neurological disorders, immune function, and cancer metabolism.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Used in drug development to study the absorption, distribution, metabolism, and excretion (ADME) of compounds that interact with or modulate the kynurenine pathway.
• Biomarker Assay Development: Facilitates the development and validation of highly sensitive and specific clinical diagnostic assays for biomarkers associated with oxidative stress and neuroinflammation.
• Stable Isotope Labeling Studies: The carbon-13 label allows for advanced metabolic flux analysis to understand the dynamics and regulation of biochemical pathways in cell culture or model organisms.

Basic Information

Product Name	3-Hydroxy-Dl-Kynurenine-(Butyric-1,2-13C2) Dihydrobromide
CAS No.	1313734-57-4
Molecular Formula	C11H1513C2Br2N2O4 *
Molecular Weight	Contact for details
Synonyms	DL-3-Hydroxykynurenine-1,2-13C2 Dihydrobromide; (±)-3-Hydroxykynurenine (Butyric-1,2-13C2) Dihydrobromide; 3-Hydroxy-DL-kynurenine-1,2-13C2 dibromide; 2-Amino-4-(3-hydroxyanthraniloyl)butyric acid-1,2-13C2 Dihydrobromide; 3-HK-13C2 Dihydrobromide; 3-Hydroxykynurenine-13C2 Dihydrobromide; HKYN-13C2 Dihydrobromide
EINECS	Contact for details

* Formula denotes carbon-13 enrichment at the 1 and 2 positions of the butyric acid side chain.

Quality Control

Every batch of our 3-Hydroxy-Dl-Kynurenine-(Butyric-1,2-13C2) Dihydrobromide is manufactured and analyzed under strict quality management protocols to ensure the highest standards of isotopic purity and chemical identity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with research-grade standards. Comprehensive Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isotopic Enrichment	≥ 99 atom % 13C
Isotopic Purity	≥ 99% 13C2
Water Content (KF)	≤ 2.0 %
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.