Description

Dnqx Disodiumsalt CAS NO 1312992-24-7 is a high-purity, water-soluble salt form of the potent and selective AMPA/kainate receptor antagonist, 6,7-Dinitroquinoxaline-2,3-dione. This compound is a critical research tool for neuropharmacological studies, enabling precise investigation of glutamatergic signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and biotechnology companies focused on neurological disorders, pain research, and neuroprotection.

Application

• Neuroscience Research: As a selective non-NMDA glutamate receptor antagonist for in vitro and in vivo studies of synaptic transmission, excitotoxicity, and neuronal plasticity.
• Pharmacological Screening: Used as a reference standard in high-throughput assays to identify and characterize novel compounds targeting AMPA and kainate receptors.
• Neuroprotection Studies: Investigation of mechanisms in stroke, traumatic brain injury, and neurodegenerative diseases like Alzheimer's and Parkinson's.
• Electrophysiology: A key reagent for patch-clamp experiments to block AMPA/kainate receptor-mediated currents, allowing isolation of NMDA receptor components.
• Biochemical Assay Development: Serves as a control compound in the development of receptor binding and functional cell-based assays.
• Academic & Institutional Research: Fundamental research in university and government laboratories exploring the role of glutamate in the central nervous system.

Basic Information

Product Name	Dnqx Disodiumsalt
CAS No.	1312992-24-7
Molecular Formula	C8H2N4Na2O7
Molecular Weight	328.12 g/mol
Synonyms	6,7-Dinitro-1,4-dihydro-2,3-quinoxalinedione disodium salt; DNQX disodium salt; 6,7-Dinitroquinoxaline-2,3-dione disodium salt; FG 9041 disodium; AMPA/Kainate receptor antagonist DNQX-Na2
EINECS	Contact for details

Quality Control

Our Dnqx Disodiumsalt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Heavy Metals	<20 ppm
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.