Description

Tak-659 Dihydrochloride is a high-purity, small molecule chemical compound primarily utilized in pharmaceutical research and development. This compound serves as a critical research-grade intermediate or reference standard for investigating novel therapeutic pathways. It is essential for organizations engaged in preclinical studies, biochemical assay development, and drug discovery programs, particularly those targeting specific kinase-related mechanisms.

Application

• Pharmaceutical Research & Development (R&D): Acts as a key biochemical tool and reference standard in drug discovery pipelines.
• Preclinical Studies: Used in in vitro and in vivo studies to evaluate pharmacological activity and mechanism of action.
• Biochemical Assay Development: Serves as a critical component for developing and validating high-throughput screening assays.
• Academic Research: Utilized in university and institutional labs for basic science research into cellular signaling pathways.
• Contract Research Organizations (CROs): Employed as a standardized material for client-sponsored research projects and testing services.
• Chemical Synthesis: Functions as a building block or precursor for the synthesis of more complex target molecules in medicinal chemistry.

Basic Information

Product Name	Tak-659 Dihydrochloride
CAS No.	1312691-41-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	TAK-659 2HCl; TAK659 dihydrochloride; Sapanisertib dihydrochloride (Note: Verify specific application); (S)-1-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea dihydrochloride; INCB050465 (Potential development code); Research Compound 1312691-41-0; Kinase Inhibitor 1312691-41-0
EINECS	Contact for details

Quality Control

Our Tak-659 Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results for assay, related substances, residual solvents, and other critical parameters. We adhere to cGMP principles where applicable to support our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Ensure the storage area is well-ventilated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.