Description

1-Methyl-3-Trifluoromethyl-1H-Pyridin-2-One is a high-value, fluorinated heterocyclic building block essential for advanced chemical synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the trifluoromethyl group, enabling the development of novel compounds with enhanced metabolic stability and bioavailability. This intermediate is critically needed by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for creating next-generation active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group improves lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated components.
• Chemical Biology & Proteomics: Employed as a building block for designing chemical probes and affinity tags to study biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring fluorinated pyridone scaffolds.

Basic Information

Product Name	1-Methyl-3-Trifluoromethyl-1H-Pyridin-2-One
CAS No.	1311829-52-3
Molecular Formula	C7H5F3N2O
Molecular Weight	190.12 g/mol
Synonyms	1-Methyl-3-(trifluoromethyl)-1H-pyridin-2-one; 1-Methyl-3-(trifluoromethyl)-2(1H)-pyridinone; 3-Trifluoromethyl-1-methyl-2-pyridone; 1-Methyl-3-trifluoromethylpyridin-2(1H)-one; 2(1H)-Pyridinone, 1-methyl-3-(trifluoromethyl)-; 1-Methyl-3-trifluoromethyl-1H-pyridin-2-one
EINECS	Contact for details

Quality Control

Our production of 1-Methyl-3-Trifluoromethyl-1H-Pyridin-2-One adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure consistency and reliability for your critical syntheses. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.