Description

Tubastatin A Hydrochloride is a potent, cell-permeable, and selective inhibitor of histone deacetylase 6 (HDAC6). This compound matters for researchers and developers as it provides a critical tool for probing the biological functions of HDAC6, a key regulator of cytoplasmic microtubule dynamics and protein aggregation. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, neurodegenerative diseases, and immunology. The product is supplied as a high-purity reference standard and research chemical.

Application

• Biochemical Research: Used as a selective HDAC6 inhibitor to study tubulin acetylation, cell motility, and aggresome formation in various cellular models.
• Drug Discovery & Development: Serves as a lead compound or pharmacological tool in preclinical studies for cancers, neurodegenerative disorders (like Alzheimer's and Parkinson's), and inflammatory diseases.
• Epigenetics & Cell Signaling Studies: Enables investigation into the role of HDAC6 in epigenetic regulation, protein degradation pathways, and stress response mechanisms.
• Neuroscience Research: Applied in models to understand HDAC6's function in axonal transport, synaptic plasticity, and tau protein pathology.
• Immunology Research: Utilized to explore the modulation of immune cell function and cytokine production through HDAC6 inhibition.
• Reference Standard: Acts as a certified reference material for analytical method development, validation, and quality control in pharmaceutical analysis.

Basic Information

Product Name	Tubastatin A Hydrochloride
CAS No.	1310693-92-5
Molecular Formula	C20H21N3O2 • HCl
Molecular Weight	363.86 g/mol (as free base: 327.40)
Synonyms	Tubastatin A HCl; N-Hydroxy-4-[[(2S)-2-[[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]amino]-1-methyl-2-oxoethyl]amino]methyl]benzamide hydrochloride; HDAC6 Inhibitor, Tubastatin A; (S)-N-Hydroxy-4-((2-((S)-2-(1H-indol-3-yl)-1-methylamino-1-oxopropan-2-ylamino)-1-methyl-2-oxoethylamino)methyl)benzamide hydrochloride
EINECS	Contact for details

Quality Control

Our Tubastatin A Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment to ensure compliance with research-grade standards and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.