Description

3-tert-Butyloxycarbonylamino-2-Fluoropyridine-5-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is valued for its role in facilitating efficient cross-coupling reactions, particularly in the construction of complex heterocyclic molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and functional materials. CAS No. 1310405-07-2.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those containing fluorinated pyridine scaffolds for enhanced metabolic stability and bioavailability.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical boronic ester reagent for the formation of carbon-carbon bonds, enabling the construction of complex biaryl and heterobiaryl structures.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that leverage the fluoropyridine moiety for improved activity.
• Material Science & OLED Development: Employed as a building block for creating organic semiconductors, ligands for catalysts, and emissive layers in electronic devices.
• Chemical Biology & Probe Synthesis: Facilitates the creation of labeled compounds and molecular probes for biochemical and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical producers for bespoke synthesis projects requiring high-fidelity boronic acid derivatives.

Basic Information

Item	Detail
Product Name	3-tert-Butyloxycarbonylamino-2-Fluoropyridine-5-Boronic Acid Pinacol Ester
CAS No.	1310405-07-2
Molecular Formula	C16H24BFN2O4
Molecular Weight	338.19 g/mol
Synonyms	5-Boronic Acid, 3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-fluoropyridine, Pinacol Ester; 2-Fluoro-3-((tert-butoxycarbonyl)amino)pyridine-5-boronic Acid Pinacol Ester; 3-(Boc-amino)-2-fluoropyridine-5-boronic Acid Pinacol Ester; 3-Boc-amino-2-fluoro-5-pyridineboronic Acid Pinacol Ester; 2-Fluoro-3-(N-Boc-amino)pyridin-5-ylboronic Acid Pinacol Ester; N-Boc-2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine; 1310405-07-2
EINECS	Contact for details

Quality Control

Our 3-tert-Butyloxycarbonylamino-2-Fluoropyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for GMP-grade intermediates and advanced research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.