Description

2-Fluoro-3-Formylpyridine-4-Boronic Acid Pinacol Ester is a high-value, multifunctional heterocyclic building block essential for modern synthetic chemistry. This compound matters because it combines three distinct reactive handles—a formyl group, a protected boronic acid, and a fluorine substituent—enabling efficient, convergent synthesis of complex molecular architectures. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for constructing novel active ingredients, particularly through Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used to create novel heterocyclic compounds with potential herbicidal, fungicidal, or insecticidal activity.
• Material Science: Serves as a building block for functionalized polymers, ligands, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The pinacol-protected boronic acid moiety enables efficient palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Medicinal Chemistry Library Synthesis: Facilitates the rapid generation of diverse compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Used to develop labeled or tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	2-Fluoro-3-Formylpyridine-4-Boronic Acid Pinacol Ester
CAS No.	1310384-06-5
Molecular Formula	C₁₃H₁₅BFNO₃
Molecular Weight	263.07 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoro-3-formylpyridine; 2-Fluoro-3-formylpyridine-4-boronic acid pinacol ester; 2-Fluoro-3-pyridinecarboxaldehyde-4-boronic acid pinacol ester; (2-Fluoro-3-formylpyridin-4-yl)boronic acid pinacol ester; 4-(Pinacolatoboryl)-2-fluoro-3-formylpyridine; 2-Fluoro-3-formyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 1310384-06-5
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Every batch is characterized by NMR (¹H, ¹³C, ¹⁹F, ¹¹B) and HPLC to confirm identity and purity. Certificates of Analysis (COA) detailing all analytical results are available upon request. We adhere to a strict quality management system to guarantee batch-to-batch consistency and supply reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.