Description

2-Fluoro-3-Methylpyridine-4-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. This compound is a key reagent in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific fluorinated pyridine motifs.
• Material Science Research: Employed in the creation of novel organic electronic materials, such as ligands for OLEDs and other functional polymers.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile handle for the late-stage functionalization of complex molecules in drug discovery programs.
• Catalyst & Ligand Development: Used to prepare novel bidentate or monodentate ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Item	Details
Product Name	2-Fluoro-3-Methylpyridine-4-Boronic Acid Pinacol Ester
CAS No.	1310383-57-3
Molecular Formula	C₁₂H₁₇BFNO₂
Molecular Weight	237.08 g/mol
Synonyms	2-Fluoro-3-methylpyridine-4-boronic acid pinacol ester; (2-Fluoro-3-methylpyridin-4-yl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(2-fluoro-3-methyl-4-pyridinyl)-1,3,2-dioxaborolane; 2-(2-Fluoro-3-methylpyridin-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (2-fluoro-3-methylpyridin-4-yl)boronate; 1310383-57-3; Boronic acid, B-(2-fluoro-3-methyl-4-pyridinyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-Methylpyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality systems. Every batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ¹⁹F, ¹¹B) and HPLC purity analysis, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support customer audits and regulatory documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.