Description

Bace1-In-1 CAS NO 1310347-50-2 is a potent and selective small molecule inhibitor of the β-site Amyloid precursor protein Cleaving Enzyme 1 (BACE1), a key therapeutic target in Alzheimer's disease research. This high-purity compound is essential for advancing neurological studies, enabling researchers to investigate disease mechanisms and evaluate potential treatment pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neurodegenerative disorders and drug discovery.

Application

• Alzheimer's Disease Research: Used as a critical tool compound to study the role of BACE1 in amyloid-beta peptide production and plaque formation.
• Drug Discovery & Development: Serves as a reference standard and a lead compound for screening and developing novel BACE1 inhibitors.
• Biochemical Assays: Employed in in vitro enzymatic assays to measure BACE1 inhibition potency and selectivity.
• Cellular & Molecular Biology Studies: Facilitates research into APP processing and downstream signaling pathways in neuronal cell models.
• Preclinical Pharmacology: Used in animal model studies to evaluate the efficacy and pharmacokinetics of BACE1-targeted therapies.
• High-Throughput Screening (HTS): Acts as a control or validation compound in large-scale screening campaigns for neurological targets.

Basic Information

Product Name	Bace1-In-1
CAS No.	1310347-50-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	BACE1 Inhibitor 1; BACE-1 Inhibitor; β-Secretase Inhibitor; (2S,3R)-3-(4-Chlorophenyl)-2-(4-fluorophenyl)-1-[(1S)-1-phenylethyl]pyrrolidine-5-carboxamide; AZD3839; HPP854; Amyloid precursor protein cleaving enzyme 1 inhibitor
EINECS	Contact for details

Quality Control

Our Bace1-In-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and potency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay results, and relevant analytical data to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.