Description

5-Fluoro-3-Nitropyridine-2-Boronic Acid Pinacol Ester is a high-value, multi-functional boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, to construct complex heterocyclic scaffolds. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated pyridine cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific fluorinated heterocyclic structures.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester partner for palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysis, and other functional organic compounds.
• Chemical Biology & Probe Development: Useful for creating molecular probes and tool compounds for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs serving the life sciences sector.

Basic Information

Item	Details
Product Name	5-Fluoro-3-Nitropyridine-2-Boronic Acid Pinacol Ester
CAS No.	1309982-34-0
Molecular Formula	C11H14BFN2O4
Molecular Weight	268.05 g/mol
Synonyms	5-Fluoro-3-nitro-2-pyridineboronic acid pinacol ester; 2-(5-Fluoro-3-nitropyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (5-Fluoro-3-nitropyridin-2-yl)boronic acid pinacol ester; 5-Fluoro-3-nitropyridine-2-boronic acid neopentyl glycol ester (common alternative); 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-fluoro-3-nitropyridine; PINACOL 5-FLUORO-3-NITROPYRIDINE-2-BORONATE; 1309982-34-0 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 5-Fluoro-3-Nitropyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.