Description

Methyl Methanethiosulfonate-13C is a stable isotope-labeled analog of methyl methanethiosulfonate (MMTS), where the methyl group is enriched with carbon-13. This compound is a critical reagent in chemical biology and proteomics research, primarily used as a selective cysteine-modifying agent for protein structure-function studies and mass spectrometry-based quantitative analysis. It is essential for researchers in pharmaceutical development, academic biochemistry, and contract research organizations (CROs) requiring high-purity isotopic tracers for accurate metabolic and proteomic profiling.

Application

• Proteomics & Chemical Biology: Selective labeling and protection of cysteine residues in proteins for structural analysis and mapping.
• Isotope-Labeled Internal Standards: Used in quantitative mass spectrometry (MS) for accurate protein and peptide quantification.
• Bioconjugation & Protein Engineering: A key building block for creating site-specifically modified proteins and antibody-drug conjugates (ADCs).
• Metabolic Pathway Tracing: Employed in studies utilizing 13C-labeled compounds to trace biochemical pathways.
• Pharmaceutical R&D: Supports drug discovery efforts, particularly in target identification and validation involving thiol-reactive mechanisms.
• Analytical Reference Standard: Serves as a high-purity certified reference material (CRM) for method development and validation in analytical laboratories.

Basic Information

Product Name	Methyl Methanethiosulfonate-13C
CAS No.	1309943-60-9
Molecular Formula	13CH3SSO2CH3
Molecular Weight	127.18 g/mol (for 13C labeled)
Synonyms	Methyl Methanethiosulfonate-13C; [13C]Methyl Methanethiosulfonate; MMTS-13C; S-Methyl methanethiosulfonate-13C; Methylthiosulfonylmethane-13C; Methanesulfonothioic acid S-methyl ester-13C; 13C-Labeled Methyl Methanethiosulfonate
EINECS	Contact for details

Quality Control

Our Methyl Methanethiosulfonate-13C is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C), chemical purity (by HPLC/NMR), and identity confirmation. We adhere to cGMP principles for research chemicals, ensuring traceability, consistency, and reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) in a cool, dry, and well-ventilated place. Due to its properties of being easily oxidized and highly volatile, prolonged exposure to air, moisture, or elevated temperatures should be avoided. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (13C NMR/MS)	≥99 atom % 13C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.