Description

Itk Inhibitor 2 CAS NO 1309784-09-5 is a potent and selective small molecule inhibitor of Interleukin-2-inducible T-cell kinase (ITK), a key signaling molecule in T-cell and mast cell activation. This compound is a critical research tool for immunologists and drug discovery scientists investigating T-cell receptor signaling pathways and inflammatory responses. It is primarily utilized in preclinical research for the development of novel therapeutics targeting autoimmune diseases, allergic disorders, and certain cancers.

Application

• Biochemical Research: Used as a selective probe to study ITK-dependent signaling cascades in T-lymphocytes and mast cells.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening and structure-activity relationship (SAR) studies for immunomodulators.
• Autoimmune Disease Research: Investigated in in vitro and in vivo models of conditions like rheumatoid arthritis, psoriasis, and inflammatory bowel disease to validate ITK as a therapeutic target.
• Allergy and Asthma Research: Applied in studies to inhibit mast cell degranulation and cytokine production, relevant to allergic reactions and asthma pathophysiology.
• Oncology Research: Explored for its potential to modulate the tumor microenvironment by affecting T-cell function in certain hematological cancers.
• Cell-Based Assays: A key reagent in functional cellular assays to measure inhibition of cytokine release (e.g., IL-2) or phosphorylation events downstream of the T-cell receptor.

Basic Information

Product Name	Itk Inhibitor 2
CAS No.	1309784-09-5
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	BMS-509744; (R)-5-((5-(4-((2,4-Difluorophenoxy)methyl)benzyl)-1,3,4-oxadiazol-2-yl)amino)-1-methyl-1H-pyrazole-4-carbonitrile; ITK Inhibitor (BMS-509744); Interleukin-2-inducible T-cell Kinase Inhibitor 2; 1-Methyl-5-[[5-[[4-[(2,4-difluorophenoxy)methyl]phenyl]methyl]-1,3,4-oxadiazol-2-yl]amino]-1H-pyrazole-4-carbonitrile
EINECS	Contact for details

Quality Control

Our Itk Inhibitor 2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade material standards. Specifications are designed to meet the rigorous demands of pharmaceutical R&D and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.