Description

Gpr40 Activator 1 CAS NO 1309435-60-6 is a potent and selective small molecule agonist for the G-protein-coupled receptor 40 (GPR40), also known as free fatty acid receptor 1 (FFAR1). This compound is of significant interest for its role in modulating glucose-dependent insulin secretion, making it a valuable pharmacological tool for metabolic research. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on diabetes, metabolic syndrome, and novel therapeutic target validation.

Application

• Pharmacological Research Tool: Used in in vitro and in vivo studies to investigate GPR40/FFAR1 signaling pathways and their physiological roles.
• Drug Discovery & Development: Serves as a reference compound or lead structure for developing new therapeutics targeting type 2 diabetes and metabolic disorders.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) campaigns and functional assays (e.g., calcium flux, cAMP) to identify and characterize new GPR40 modulators.
• Academic & Institutional Research: Supports basic science research into insulin secretion mechanisms, β-cell function, and energy metabolism.
• Preclinical Studies: Utilized in animal models to evaluate the efficacy and pharmacokinetic profiles of GPR40-targeting interventions.

Basic Information

Product Name	Gpr40 Activator 1
CAS No.	1309435-60-6
Molecular Formula	C₂₀H₂₀F₃N₃O₃
Molecular Weight	407.39 g/mol
Synonyms	GPR40 Activator 1; FFAR1 Agonist; TAK-875 (Fasiglifam); (3S)-6-({2',6'-Dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-carboxylic Acid; AMG 837; GW9508; Compound 1; GPR40/FFAR1 agonist.
EINECS	Contact for details

Quality Control

Our Gpr40 Activator 1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and analytical methods are provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.