Description

Cx-4945 (Sodium Salt) is a potent and selective small molecule inhibitor of Casein Kinase 2 (CK2), a serine/threonine kinase implicated in numerous cellular processes. This compound is a critical research tool for investigating CK2 signaling pathways in oncology, virology, and inflammatory diseases. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies for preclinical studies and drug discovery programs. The high-purity sodium salt form offers enhanced solubility for in vitro and in vivo applications.

Application

• Oncology Research: Investigation of CK2's role in cancer cell proliferation, apoptosis, and tumor progression.
• Drug Discovery & Development: Serving as a lead compound or pharmacological probe in high-throughput screening and target validation studies.
• Virology Studies: Research into viral replication mechanisms, as CK2 is known to phosphorylate proteins of various viruses.
• Inflammatory & Autoimmune Disease Research: Exploration of CK2 inhibition as a potential therapeutic strategy for conditions like rheumatoid arthritis.
• Cell Signaling Pathway Analysis: Used to dissect the complex networks regulated by CK2 in normal and diseased states.
• Biochemical Assay Development: As a standard or control in enzymatic assays to measure CK2 activity and inhibitor potency.

Basic Information

Product Name	Cx-4945 (Sodium Salt)
CAS No.	1309357-15-0
Molecular Formula	C₂₁H₁₇ClN₆O₃ • Na
Molecular Weight	459.84 g/mol
Synonyms	Silmitasertib Sodium Salt; CX-4945 Sodium; 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid Sodium Salt; Casein Kinase II Inhibitor CX-4945 Sodium; CK2 Inhibitor CX-4945 Sodium Salt
EINECS	Contact for details

Quality Control

Our Cx-4945 (Sodium Salt) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.