Description

Diltiazem-D6 Hydrochloride is a deuterium-labeled analog of the calcium channel blocker Diltiazem, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is essential for ensuring accuracy and reliability in pharmacokinetic, metabolic, and bioanalytical studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug development and quality control.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of Diltiazem and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Serves as a stable, isotopically labeled standard to improve assay precision, accuracy, and reproducibility.
• Pharmaceutical Impurity Profiling: Used in stability studies and impurity identification to meet regulatory requirements for drug substance characterization.
• Forensic and Clinical Toxicology: Assists in the accurate measurement of Diltiazem levels for therapeutic drug monitoring or forensic investigations.

Basic Information

Product Name	Diltiazem-D6 Hydrochloride
CAS No.	1309283-34-8
Molecular Formula	C22H20D6ClN2O4S•HCl
Molecular Weight	~ 518.0 g/mol
Synonyms	(2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate-d6 hydrochloride; Diltiazem-d6 HCl; Diltiazem (hexadeuterated) hydrochloride; cis-(+)-Diltiazem-d6 hydrochloride; 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, hydrochloride, hexadeuterated
EINECS	Contact for details

Quality Control

Our Diltiazem-D6 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic enrichment, and other critical parameters. We adhere to relevant industry standards for reference materials to guarantee reliable and reproducible performance in your sensitive analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.