Description

Citalopram-D3 CAS NO 1309283-28-0 is a deuterated analog of the widely used selective serotonin reuptake inhibitor (SSRI), Citalopram. This stable isotope-labeled compound is an essential internal standard for the precise and accurate quantification of Citalopram in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in bioanalytical method development, pharmacokinetic studies, and drug metabolism research.

Application

• Bioanalytical Internal Standard: Serves as a critical reference compound in quantitative Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for drug level monitoring in plasma, serum, and tissue samples.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of Citalopram absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic & Clinical Toxicology: Used in assays to confirm and quantify Citalopram exposure in forensic investigations or therapeutic drug monitoring (TDM) programs.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of potential deuterated impurities or related substances in drug substance batches.
• Method Development & Validation: Essential for developing, optimizing, and validating robust, regulatory-compliant analytical methods for Citalopram.
• Stable Isotope Dilution Assays: Provides the foundation for highly precise quantification techniques that correct for sample preparation and ionization variability.

Basic Information

Product Name	Citalopram-D3
CAS No.	1309283-28-0
Molecular Formula	C20H18D3FN2O
Molecular Weight	327.41 g/mol
Synonyms	1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-(trideuteriomethyl)isobenzofuran-3-carbonitrile; Citalopram-d3; Citalopram (phenyl-d3); Deuterated Citalopram; Celexa-d3; (±)-Citalopram-d3; 5-[(Methyl-d3)oxy]phthalancarbonitrile-d3 derivative
EINECS	Contact for details

Quality Control

Our Citalopram-D3 is manufactured under strict quality control protocols to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (e.g., D3 > 99%), chemical purity (by HPLC), and confirmation of structure (by NMR and MS). We adhere to relevant industry standards for reference materials to ensure reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.