Description

(S)-Atenolol-D7 CAS NO 1309283-20-2 is a high-purity, deuterium-labeled internal standard critical for precise quantitative analysis in bioanalytical and pharmacokinetic studies. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) methods. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities for method development, validation, and routine drug metabolism and pharmacokinetics (DMPK) analysis.

Application

• Internal Standard for LC-MS/MS Quantification: Used as a critical reference compound for the accurate measurement of atenolol and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioequivalence Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Drug Metabolism Research: Facilitates the identification and quantification of metabolite profiles, aiding in the understanding of drug biotransformation pathways.
• Forensic and Clinical Toxicology: Supports accurate assay development for the detection and quantification of atenolol in forensic analysis and therapeutic drug monitoring (TDM).
• Method Development and Validation: Serves as a key component in developing robust, sensitive, and selective analytical methods compliant with FDA, EMA, and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Used in analytical labs to ensure the purity and consistency of atenolol-based drug products through advanced spectroscopic techniques.

Basic Information

Product Name	(S)-Atenolol-D7
CAS No.	1309283-20-2
Molecular Formula	C14H15D7N2O3
Molecular Weight	273.36 g/mol
Synonyms	(S)-2-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetamide-D7; Atenolol-d7; (S)-Atenolol D7; Deuterated (S)-Atenolol; (S)-4-[2-Hydroxy-3-[(propan-2-yl)amino]propoxy]phenylacetamide-d7; (S)-Atenolol (phenyl-D7); Atenolol (ring-D7) (S)-isomer
EINECS	Contact for details

Quality Control

Every batch of (S)-Atenolol-D7 is manufactured and analyzed under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Our quality commitment includes comprehensive testing via NMR, HPLC, and MS to confirm isotopic enrichment (typically ≥98% D) and chemical purity (typically ≥95%). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for identity, purity, and isotopic content.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.