Description

(2-Chloro-5-Fluorophenyl)Methanesulfonyl Chloride is a high-purity sulfonyl chloride derivative, a critical building block in modern organic synthesis. Its value lies in its dual reactive sites, enabling the efficient introduction of the (2-chloro-5-fluorophenyl)methanesulfonyl moiety into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in sulfonamide-based drug discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require specific halogenated aryl sulfonyl structures.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialized polymers and functional materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and enzyme inhibitors for biochemical research.
• Custom Synthesis: A versatile reagent for contract research organizations (CROs) and CDMOs engaged in custom synthesis and process development.

Basic Information

Product Name	(2-Chloro-5-Fluorophenyl)Methanesulfonyl Chloride
CAS No.	1308384-59-9
Molecular Formula	C7H5Cl2FO2S
Molecular Weight	243.08 g/mol
Synonyms	2-Chloro-5-fluorobenzylsulfonyl chloride; 1-(Chlorosulfonyl)methyl-2-chloro-5-fluorobenzene; (2-Chloro-5-fluorophenyl)methyl sulfonyl chloride; α-Chlorosulfonyl-2-chloro-5-fluorotoluene; 2-Chloro-α-chlorosulfonyl-5-fluorotoluene; 2-Chloro-5-fluoro-α-toluenesulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of (2-Chloro-5-Fluorophenyl)Methanesulfonyl Chloride is manufactured and tested under strict quality management systems. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, GC, and NMR, is performed to verify identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.