Description

(4-Chloro-2-Fluorophenyl)Methanesulfonyl Chloride is a high-purity, multi-functional chemical building block essential for advanced organic synthesis. This compound serves as a critical sulfonylating agent and versatile intermediate in the development of complex molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for constructing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the bioactivity of the sulfonyl chloride moiety.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling proteins or modifying biomolecules in probe development.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring the introduction of a (4-chloro-2-fluorophenyl)methanesulfonyl group.

Basic Information

Product Name	(4-Chloro-2-Fluorophenyl)Methanesulfonyl Chloride
CAS No.	1308384-53-3
Molecular Formula	C7H5Cl2FO2S
Molecular Weight	243.08 g/mol
Synonyms	4-Chloro-2-fluorobenzylsulfonyl chloride; 1-(Chlorosulfonylmethyl)-4-chloro-2-fluorobenzene; (4-Chloro-2-fluorophenyl)methanesulfonyl chloride; 2-Fluoro-4-chlorobenzylsulfonyl chloride; α-Chlorosulfonyl-4-chloro-2-fluorotoluene; 4-Chloro-2-fluoro-α-(chlorosulfonyl)toluene; (4-Chloro-2-fluorobenzyl)sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of (4-Chloro-2-Fluorophenyl)Methanesulfonyl Chloride is manufactured and tested under a strict quality management system to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our commitment to quality supports compliance in cGMP and ISO 9001 environments for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.