Description

tert-Butyl 4-(Bromomethyl)-3,3-difluoropiperidine-1-carboxylate is a high-value, multi-functional building block in advanced organic synthesis, characterized by its reactive bromomethyl and difluorinated piperidine scaffold. This compound is essential for medicinal chemistry research and development, enabling the efficient introduction of key pharmacophores and facilitating structure-activity relationship (SAR) studies. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for creating novel active pharmaceutical ingredients (APIs) and other complex molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in CNS (Central Nervous System) and oncology research.
• Medicinal Chemistry Building Block: Used for the late-stage functionalization and diversification of lead compounds, leveraging the reactivity of the bromomethyl group for cross-coupling or substitution reactions.
• Fluorinated Compound Synthesis: Serves as a key source of a difluorinated piperidine moiety, a privileged structure in drug design known to improve metabolic stability and membrane permeability.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed in the construction of linkers and warhead components for targeted protein degradation therapeutics.
• Agrochemical Research: Used in the discovery and synthesis of new generation pesticides and herbicides that incorporate fluorinated heterocycles.
• Chemical Biology Probe Development: Facilitates the creation of tool compounds for studying enzyme function and biological pathways.

Basic Information

Product Name	tert-Butyl 4-(Bromomethyl)-3,3-difluoropiperidine-1-carboxylate
CAS No.	1303974-03-9
Molecular Formula	C12H20BrF2NO2
Molecular Weight	328.20 g/mol
Synonyms	1-Boc-4-(bromomethyl)-3,3-difluoropiperidine; 3,3-Difluoro-4-(bromomethyl)piperidine-1-carboxylic acid tert-butyl ester; 4-(Bromomethyl)-3,3-difluoro-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(bromomethyl)-3,3-difluoro-1-piperidinecarboxylate; 1-(tert-Butoxycarbonyl)-4-(bromomethyl)-3,3-difluoropiperidine; Boc-4-(bromomethyl)-3,3-difluoropiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Bromomethyl)-3,3-difluoropiperidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP (current Good Manufacturing Practice) standards where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this moisture-sensitive material from atmospheric humidity. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.