Description

Plx5622 is a potent and selective small molecule inhibitor of the CSF1R (Colony Stimulating Factor 1 Receptor) tyrosine kinase. This compound is a critical research tool for studying the role of microglia and macrophages in various disease models, particularly in neuroscience and oncology. It is essential for scientists and pharmaceutical developers in the fields of neuroinflammation, immuno-oncology, and autoimmune disease research who require high-purity, reliable chemical probes to validate targets and elucidate biological mechanisms.

Application

• Microglia Depletion Studies: Used in preclinical research to selectively deplete microglia in the central nervous system to study their function in neurodegenerative diseases (e.g., Alzheimer's, Parkinson's), neuropathic pain, and brain injury.
• Immuno-oncology Research: Investigates the role of tumor-associated macrophages (TAMs) in tumor progression, metastasis, and response to therapy by inhibiting CSF1R signaling.
• Inflammatory Disease Models: Applied in research models for rheumatoid arthritis, multiple sclerosis, and other conditions where CSF1R-dependent macrophages play a key pathological role.
• Cell Culture & In Vitro Assays: Serves as a key reagent in cell-based assays to inhibit CSF1R phosphorylation and downstream signaling pathways in primary macrophages or cell lines.
• Drug Discovery & Target Validation: Acts as a reference standard and pharmacological tool compound for screening and validating new CSF1R inhibitors in drug development pipelines.

Basic Information

Product Name	Plx5622
CAS No.	1303420-67-8
Molecular Formula	C₂₁H₂₂F₃N₅O₂
Molecular Weight	433.43 g/mol
Synonyms	PLX-5622; PLX 5622; CSF1R Inhibitor PLX5622; 5-((5-Fluoro-2-((3-((trifluoromethyl)thio)phenyl)amino)pyrimidin-4-yl)amino)-2-methylbenzenesulfonamide; FMS Inhibitor PLX5622; Pexidartinib analog; Colony Stimulating Factor 1 Receptor Inhibitor
EINECS	Contact for details

Quality Control

Our Plx5622 is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for advanced research applications. Each lot is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available upon request to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.