Description

n-Desmethyl Tapentadol is a key pharmaceutical intermediate and an active metabolite of the centrally-acting analgesic Tapentadol. This compound is of significant importance for research and development in the synthesis of novel pain management therapeutics and for conducting detailed pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard providers, and manufacturers engaged in the production of advanced analgesic agents.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of Tapentadol and its structural analogs.
• Reference Standard: Used as a high-purity standard in analytical chemistry for method development and validation in bioanalytical studies.
• Metabolite Research: Essential for in-vitro and in-vivo studies investigating the metabolism, pharmacokinetics, and pharmacodynamics of Tapentadol.
• Impurity Profiling: Serves as a specified impurity standard for quality control and regulatory filing (e.g., ICH guidelines) of Tapentadol Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry: Used in research programs aimed at designing new opioid receptor agonists with improved efficacy and safety profiles.

Basic Information

Product Name	n-Desmethyl Tapentadol
CAS No.	1300037-83-5
Molecular Formula	C13H21NO2
Molecular Weight	223.31 g/mol
Synonyms	3-[(1R,2R)-3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol; O-Desmethyl Tapentadol; Tapentadol Metabolite; N-Demethyl Tapentadol; (1R,2R)-3-(Dimethylamino)-1-ethyl-2-methylpropylphenol; 1300037-83-5; GR 66628X (related to precursor chemistry)
EINECS	Contact for details

Quality Control

Our n-Desmethyl Tapentadol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR, MS), to ensure it meets the stringent requirements for pharmaceutical research and reference standard applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.