Description

Bromodomain Inhibitor-8 is a potent and selective small molecule inhibitor designed to target bromodomain-containing proteins, specifically the BET (Bromodomain and Extra-Terminal) family. This compound matters for its critical role in epigenetic research and drug discovery, enabling the study of gene regulation and transcriptional control linked to cancer, inflammation, and other diseases. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in developing novel therapeutics.

Application

• Epigenetics Research: A key tool for investigating the role of BET bromodomains in chromatin remodeling and gene expression.
• Oncology Studies: Used in preclinical research to explore the inhibition of BRD4 and other BET proteins as a therapeutic strategy for various cancers.
• Inflammatory Disease Models: Applied in research targeting transcriptional programs in autoimmune and inflammatory conditions.
• Chemical Probe Development: Serves as a starting point or reference compound for developing more selective bromodomain inhibitors.
• High-Throughput Screening (HTS): Utilized as a control or reference standard in assay development and screening campaigns.
• Mechanism of Action Studies: Helps elucidate downstream signaling pathways and cellular responses to BET inhibition.

Basic Information

Product Name	Bromodomain Inhibitor-8
CAS No.	1300031-70-2
Molecular Formula	C21H19N5O2S
Molecular Weight	405.47 g/mol
Synonyms	Bromosporine; (+)-Bromosporine; BRD Inhibitor; BET Bromodomain Inhibitor; 1,3-Dimethyl-6-[(2-methyl-1H-imidazol-1-yl)methyl]-5-[(4-phenyl-1,3-thiazol-2-yl)methyl]pyrimidine-2,4(1H,3H)-dione; GSK 046; BROMO-8; BRD4 Inhibitor VIII
EINECS	Contact for details

Quality Control

Our Bromodomain Inhibitor-8 is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and water content determination. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For daily use, allow the vial to equilibrate to room temperature in a desiccator before opening to minimize exposure to moisture. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.