Description

Gsk1324726A (I-Bet726) is a potent and selective small molecule inhibitor targeting the bromodomain and extra-terminal (BET) family of proteins. This compound is a critical research tool for investigating epigenetic regulation and its role in disease pathways, particularly in oncology and inflammation. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on developing novel therapeutics targeting transcriptional dysregulation.

Application

• Biomedical Research: A key chemical probe for studying the biological functions and mechanisms of BET proteins in cellular models.
• Drug Discovery & Development: Used in high-throughput screening, target validation, and as a lead compound or reference standard in oncology and immunology drug discovery programs.
• Epigenetics Studies: Facilitates research into chromatin remodeling, gene expression regulation, and the role of bromodomains in various diseases.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate the therapeutic potential of BET inhibition for cancers, inflammatory, and cardiovascular conditions.
• Biochemical Assays: Serves as a reference inhibitor in enzymatic and binding assays to characterize BET bromodomain interactions.

Basic Information

Product Name	Gsk1324726A (I-Bet726)
CAS No.	1300031-52-0
Molecular Formula	C₂₁H₂₀ClN₅O₂
Molecular Weight	409.87 g/mol
Synonyms	I-BET726; I-BET-726; GSK1324726A; GSK-1324726A; (R)-N-(4-Chlorophenyl)-2-(3,4-dihydroisoquinolin-1(2H)-yl)-2-(5-methyl-1H-pyrazol-3-yl)acetamide; (R)-2-(3,4-Dihydroisoquinolin-1(2H)-yl)-2-(5-methyl-1H-pyrazol-3-yl)-N-(4-chlorophenyl)acetamide; BET Bromodomain Inhibitor I-BET726
EINECS	Contact for details

Quality Control

Our Gsk1324726A (I-Bet726) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.