Description

Target Protein-Binding Moiety 4 is a specialized chemical building block designed for the development of targeted therapeutic agents. Its core value lies in its ability to selectively bind to specific protein targets, enabling the creation of advanced drug conjugates and diagnostic tools. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on precision medicine, particularly in oncology and autoimmune disease research.

Application

• Protac (PROteolysis TArgeting Chimera) Development: Serves as a key ligand or linker component for designing molecules that induce targeted protein degradation.
• Antibody-Drug Conjugate (ADC) Payloads: Used as a potent warhead or connecting moiety in the synthesis of next-generation ADCs for cancer therapy.
• Small Molecule Inhibitor Synthesis: Acts as a critical pharmacophore in the design of high-affinity inhibitors for challenging protein targets.
• Chemical Biology Probes: Enables the creation of tool compounds for studying protein function, localization, and interaction networks within cells.
• Radiopharmaceuticals: Incorporated into ligands for Positron Emission Tomography (PET) or Single-Photon Emission Computed Tomography (SPECT) imaging agents.
• Bifunctional Linker Chemistry: Facilitates the conjugation of different functional entities, such as drugs, dyes, or nanoparticles, to targeting antibodies or peptides.

Basic Information

Product Name	Target Protein-Binding Moiety 4
CAS No.	1300019-38-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	TPBM-4; Protein-Targeting Moiety 4; PROTAC Ligand 4; E3 Ligase Ligand 4; Targeted Degradation Moiety 4; (S,R,S)-AHPC-Me; VHL Ligand 4; (2S,4R)-1-((S)-2-(1-Cyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
EINECS	Contact for details

Quality Control

Our Target Protein-Binding Moiety 4 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the sealed vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.