Description

n-(5-Fluoro-3-Iodo-4-(Trimethylsilyl)Pyridin-2-Yl) Pivalamide is a high-value, multi-functionalized pyridine derivative designed for advanced synthetic chemistry. This compound is a critical pharmaceutical intermediate and building block for the development of novel active ingredients. It is primarily sought by R&D and process development teams in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new crop protection agents, leveraging its halogenated pyridine core for bioactivity.
• Chemical Synthesis: Serves as a versatile precursor for cross-coupling reactions (e.g., Suzuki, Stille) due to the presence of the iodine substituent.
• Material Science: Potential intermediate for creating functionalized ligands or organic electronic materials.
• R&D & Process Chemistry: Essential for medicinal chemistry programs and scale-up process development in contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	n-(5-Fluoro-3-Iodo-4-(Trimethylsilyl)Pyridin-2-Yl) Pivalamide
CAS No.	1299607-78-5
Molecular Formula	C13H20FIN2OSi
Molecular Weight	394.30 g/mol
Synonyms	2-Pivalamido-5-fluoro-3-iodo-4-(trimethylsilyl)pyridine; 5-Fluoro-3-iodo-4-(trimethylsilyl)picolinamide, N-tert-butyl-; Pivalamide, N-[5-fluoro-3-iodo-4-(trimethylsilyl)-2-pyridinyl]-; 1299607-78-5; 5-Fluoro-3-iodo-4-trimethylsilylpyridine-2-carboxamide, N-tert-butyl-; N-(5-Fluoro-3-iodo-4-trimethylsilylpyridin-2-yl)-2,2-dimethylpropanamide
EINECS	Contact for details

Quality Control

Our production of n-(5-Fluoro-3-Iodo-4-(Trimethylsilyl)Pyridin-2-Yl) Pivalamide adheres to stringent quality protocols suitable for pharmaceutical R&D. Each batch is characterized by advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system is designed to support regulatory filings and cGMP compliance for investigational applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.