Description

4-(4-Trifluoromethyl-Pyridin-2-Yl)-Benzoic Acid Methyl Ester is a high-value, multi-functional chemical intermediate characterized by its pyridine and benzoate ester structure with a trifluoromethyl substituent. This compound matters for its role as a critical building block in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated motifs into novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in developing advanced herbicides and pesticides where the CF3 group improves biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and organic synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as fluorinated polymers or small molecules for OLEDs.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated probes for studying biological systems and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A vital component for custom synthesis houses serving the global fine chemical market.

Basic Information

Product Name	4-(4-Trifluoromethyl-Pyridin-2-Yl)-Benzoic Acid Methyl Ester
CAS No.	1299607-44-5
Molecular Formula	C14H10F3NO2
Molecular Weight	281.23 g/mol
Synonyms	Methyl 4-[4-(trifluoromethyl)pyridin-2-yl]benzoate; 2-(4-Methoxycarbonylphenyl)-4-(trifluoromethyl)pyridine; Benzoic acid, 4-[4-(trifluoromethyl)-2-pyridinyl]-, methyl ester; 4-(4-Trifluoromethyl-2-pyridyl)benzoic acid methyl ester; 4-(4-(Trifluoromethyl)pyridin-2-yl)benzoic acid methyl ester; Methyl 4-(4-(trifluoromethyl)pyridin-2-yl)benzoate
EINECS	Contact for details

Quality Control

Our 4-(4-Trifluoromethyl-Pyridin-2-Yl)-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.