Description

Setmelanotide CAS NO 1294000-61-5 is a synthetic melanocortin-4 (MC4) receptor agonist peptide. This compound is of significant pharmaceutical interest for its role in regulating energy homeostasis and body weight. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel therapeutics for rare genetic disorders of obesity, such as pro-opiomelanocortin (POMC) deficiency and leptin receptor (LEPR) deficiency.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of injectable therapeutics targeting genetic obesity disorders.
• Reference Standard for analytical method development and validation in quality control laboratories.
• Pharmacological Research for studying the melanocortin pathway and energy balance mechanisms.
• Preclinical Development for efficacy and safety studies in metabolic disease models.
• Process Development for scaling up synthesis and purification of peptide-based drugs.
• Regulatory Submissions, providing high-purity material for clinical trial applications and regulatory filings.

Basic Information

Product Name	Setmelanotide
CAS No.	1294000-61-5
Molecular Formula	C₄₉H₆₈N₁₄O₁₀
Molecular Weight	1021.2 g/mol
Synonyms	Setmelanotide; BIM-22493; RM-493; L-Tyrosyl-L-arginyl-L-2-aminohexanoyl-L-cysteinyl-D-alanyl-L-tryptophyl-L-arginyl-L-tryptophyl-L-phenylalaninamide cyclic (2→7)-disulfide; UNII-4S1746GHM6; Melanocortin 4 receptor agonist; MC4R agonist; Imcivree (brand name)
EINECS	Contact for details

Quality Control

Our Setmelanotide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and stringent tests for residual solvents and related substances to ensure compliance with pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (Related Substances)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.