Description

(1-(5-Fluoropyridin-3-Ylsulfonyl)Pyrrolidin-2-Yl)Methanol is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonamide-pyrrolidine hybrid structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel therapeutic agents with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new drug candidates, particularly in areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries via parallel synthesis and structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: Serves as a core structural motif in the design of inhibitors for various enzymes, leveraging the sulfonamide and fluoropyridine pharmacophores.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways and target engagement.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for scale-up synthesis under cGMP conditions for clinical trial material production.

Basic Information

Product Name	(1-(5-Fluoropyridin-3-Ylsulfonyl)Pyrrolidin-2-Yl)Methanol
CAS No.	1291411-99-8
Molecular Formula	C10H13FN2O3S
Molecular Weight	260.29 g/mol
Synonyms	1-[(5-Fluoropyridin-3-yl)sulfonyl]pyrrolidin-2-ylmethanol; 2-Pyrrolidinemethanol, 1-[(5-fluoro-3-pyridinyl)sulfonyl]-; (1-((5-Fluoropyridin-3-yl)sulfonyl)pyrrolidin-2-yl)methanol; 1-(5-Fluoropyridine-3-sulfonyl)pyrrolidin-2-ylmethanol; 1-(5-Fluoro-3-pyridinesulfonyl)-2-pyrrolidinemethanol; 1291411-99-8; 5-Fluoro-3-((2-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)pyridine
EINECS	Contact for details

Quality Control

Our (1-(5-Fluoropyridin-3-Ylsulfonyl)Pyrrolidin-2-Yl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided for every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.