Description

4-Amino-2-Fluoronicotinaldehyde is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, enabling the introduction of both amino and aldehyde functional groups into complex molecular architectures. Pharmaceutical researchers, agrochemical developers, and specialty chemical manufacturers need this material for constructing nitrogen-containing heterocycles, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and pesticides with improved efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic semiconductors, fluorescent dyes, and photoactive materials.
• Chemical Biology Probes: Utilized to create labeled compounds and molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring specific fluorinated nicotinaldehyde derivatives.

Basic Information

Product Name	4-Amino-2-Fluoronicotinaldehyde
CAS No.	1289119-17-0
Molecular Formula	C₆H₅FN₂O
Molecular Weight	140.12 g/mol
Synonyms	2-Fluoro-4-aminonicotinaldehyde; 4-Amino-2-fluoropyridine-3-carboxaldehyde; 3-Pyridinecarboxaldehyde, 4-amino-2-fluoro-; 2-Fluoro-4-aminopyridine-3-carbaldehyde; 4-Amino-2-fluoro-3-pyridinecarboxaldehyde; 2-Fluoro-4-amino-3-formylpyridine; 4-Amino-2-fluoronicotinaldehyde; 1289119-17-0
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-2-Fluoronicotinaldehyde is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for research and commercial synthesis. Our quality protocols are designed to support cGMP (current Good Manufacturing Practice) compliance for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.