Description

5-Fluoro-3-Nitropyridine-2-Carbaldehyde is a high-purity, multi-functional organic building block, specifically a fluorinated and nitrated pyridine derivative. This compound is valued for its unique reactivity profile, offering two distinct electrophilic sites (the aldehyde and nitro groups) and a fluorine substituent for further functionalization, making it a versatile intermediate in complex synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, kinase inhibitors, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized pyridine-based ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Chemical Biology Probes: Utilized to develop molecular probes and tags for studying biological processes and enzyme mechanisms.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global R&D projects.

Basic Information

Product Name	5-Fluoro-3-Nitropyridine-2-Carbaldehyde
CAS No.	1289047-69-3
Molecular Formula	C6H3FN2O3
Molecular Weight	170.10 g/mol
Synonyms	2-Formyl-5-fluoro-3-nitropyridine; 5-Fluoro-3-nitro-2-pyridinecarboxaldehyde; 5-Fluoro-3-nitropicolinaldehyde; 3-Nitro-5-fluoropyridine-2-carbaldehyde; 2-Pyridinecarboxaldehyde, 5-fluoro-3-nitro-; 5-Fluoro-3-nitro-2-formylpyridine; 5-Fluoro-3-nitropyridine-2-carboxaldehyde
EINECS	Contact for details

Quality Control

Our 5-Fluoro-3-Nitropyridine-2-Carbaldehyde is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.