Description

(αr)-α-Hydroxy-γ-Oxo-Benzenebutanoic-D5 Acid is a deuterated derivative of a key benzenebutanoic acid intermediate, where five hydrogen atoms are replaced with the stable isotope deuterium. This deuteration is critical for enhancing metabolic stability and traceability in pharmacokinetic and metabolic studies. It is primarily utilized by research scientists and process chemists in the pharmaceutical and agrochemical industries for use as a labeled internal standard, a tracer in mass spectrometry, and a building block in the development of novel active compounds.

Application

• Pharmaceutical Research & Development: Serves as a deuterium-labeled internal standard for the accurate quantification of its non-deuterated counterpart in bioanalytical methods using LC-MS/MS.
• Metabolic Pathway Tracing: Used as a stable isotopic tracer to study drug metabolism, absorption, distribution, and excretion (ADME) profiles in preclinical research.
• Process Chemistry & Impurity Profiling: Acts as a reference material for identifying and quantifying process-related impurities and degradation products during API development and quality control.
• Synthetic Intermediate: Functions as a specialized building block for the synthesis of deuterated drug candidates, where isotopic labeling can improve metabolic properties.
• Agrochemical Research: Employed in environmental fate studies and residue analysis of related active ingredients.

Basic Information

Product Name	(αr)-α-Hydroxy-γ-Oxo-Benzenebutanoic-D5 Acid
CAS No.	1286934-16-4
Molecular Formula	C₁₀H₅D₅O₄
Molecular Weight	199.21 g/mol (approx.)
Synonyms	4-Hydroxy-4-oxo-4-phenylbutanoic-2,2,3,3,4-d5 acid; Benzenebutanoic-d5 acid, α-hydroxy-γ-oxo-; (R)-α-Hydroxy-γ-oxobenzenebutanoic-d5 acid; (Ar)-α-Hydroxy-γ-oxobenzenebutanoic-d5 acid; Phenyl-D5-succinic acid semialdehyde, α-hydroxy-; Deuterated Atrolactic acid γ-lactone precursor; 2,2,3,3,4-Pentadeutero-4-hydroxy-4-oxo-4-phenylbutanoic acid
EINECS	Contact for details

Quality Control

Every batch of (αr)-α-Hydroxy-γ-Oxo-Benzenebutanoic-D5 Acid is manufactured and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive testing including assay, deuterium enrichment (D-content) by NMR or MS, and identification of related substances. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.