Description

(R)-2-Hydroxy-4-Phenylbutyric Acid-D5 Ethyl Ester is a high-purity, deuterium-labeled chiral building block essential for advanced pharmaceutical research and development. This compound serves as a critical internal standard and synthetic intermediate for creating isotopically labeled drug candidates, enabling precise pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions specializing in medicinal chemistry and analytical method development.

Application

• Pharmaceutical Reference Standard: Acts as a deuterated internal standard for the accurate quantification of its non-labeled counterpart and related metabolites in bioanalytical assays using LC-MS/MS.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of drug candidates.
• Synthetic Intermediate: Used in the asymmetric synthesis of deuterium-labeled active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and neurological diseases.
• Proteomics and Metabolomics Research: Serves as a stable isotope-labeled probe in mass spectrometry-based studies for pathway analysis and biomarker discovery.
• Quality Control and Method Validation: Employed in analytical laboratories to validate chromatographic methods and ensure accuracy in potency and impurity testing.

Basic Information

Product Name	(R)-2-Hydroxy-4-Phenylbutyric Acid-D5 Ethyl Ester
CAS No.	1286413-90-8
Molecular Formula	C₁₂H₁₀D₅O₃
Molecular Weight	~213.27 g/mol
Synonyms	(R)-Ethyl 2-Hydroxy-4-Phenylbutyrate-d5; (R)-Ethyl 2-Hydroxy-4-Phenylbutanoate-d5; (R)-HPB-D5 Ethyl Ester; (R)-2-Hydroxy-4-Phenylbutanoic Acid-D5 Ethyl Ester; (R)-O-ethyl 2-hydroxy-4-phenylbutyrate-d5; (R)-α-Hydroxybenzenebutanoic Acid-D5 Ethyl Ester; (2R)-2-Hydroxy-4-Phenylbutyric-2,3,3,4,4-d5 Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our (R)-2-Hydroxy-4-Phenylbutyric Acid-D5 Ethyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for chiral purity, chemical purity, isotopic enrichment, and residual solvents. We adhere to cGMP principles for advanced intermediates, supporting our clients' regulatory filing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep the container in a cool, dry, and well-ventilated place. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.