Description

Lrrk2-Kinase Inhibitor CAS NO 1285515-21-0 is a potent and selective small molecule inhibitor targeting the leucine-rich repeat kinase 2 (LRRK2), a key protein implicated in the pathogenesis of Parkinson's disease. This high-purity compound is essential for preclinical research and drug discovery programs focused on neurodegenerative disorders. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in developing novel therapeutic agents.

Application

• Parkinson's Disease Research: A critical tool for in vitro and in vivo studies investigating LRRK2 kinase activity and its role in disease pathways.
• Drug Discovery & Development: Serves as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of new neuroprotective therapies.
• Biochemical Assay Development: Used to establish high-throughput screening (HTS) assays and enzymatic activity tests for LRRK2 and related kinases.
• Mechanism of Action Studies: Enables detailed pharmacological profiling to understand inhibitor binding, selectivity, and downstream signaling effects.
• Preclinical Model Validation: Employed in cellular and animal models to evaluate the efficacy and safety of LRRK2-targeting therapeutic candidates.

Basic Information

Product Name	Lrrk2-Kinase Inhibitor
CAS No.	1285515-21-0
Molecular Formula	C21H21FN6O
Molecular Weight	392.43 g/mol
Synonyms	PF-06447475; LRRK2-IN-1; PF06447475; (9H-Purin-6-yl)((1S,4S)-4-(4-(pyridin-2-yl)phenyl)cyclohexyl)amine; 1-(4-(Pyridin-2-yl)phenyl)-4-(9H-purin-6-ylamino)cyclohexanol; LRRK2 Kinase Inhibitor; LRRK2 Inhibitor
EINECS	Contact for details

Quality Control

Our Lrrk2-Kinase Inhibitor is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and NMR/LC-MS for structural confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.